Abstract: Under the background of informatization,interactive teaching mode can effectively stimulate the initiative and exploration of both sides and effectively improve the teaching effect.Taking the Road and Bridge Specialty of higher vocational colleges as an example,it discusses the hardware and software construction foundation of interactive teaching mode needed to introduce into professional courses in detail.It also takes the Bridge Design and Structure Calculation course as an example,focusing on the design concept,design content and specific implementation scheme of interactive teaching mode,and makes an empirical analysis of its application effect.The result shows that the application of interactive teaching mode greatly improves students’learning interest and efficiency,and has the value of promotion and application in other courses of Road and Bridge Specialty in higher vocational college.