Abstract: In order to research the effect of domestic waste landfill site on groundwater, making a domestic waste landfill site in Qinghai province as an example, on the basis of special hydrogeological exploration, it used analytic method to make analog computation to transportation of contaminated solute under abnormal conditions. The calculation results showed that under the hydrogeological condition of the project site, the influence range of domestic waste landfill site to groundwater is controllable.