Abstract: In order to improve the social service level of higher vocational education,realize the coordinated development of higher vocational education and regional economy, starting from the perspective of system theory and taking the symbiotic relationship between higher vocational education and regional economic development as the breakthrough point, it analyzes the problems existing in higher vocational colleges in the service of regional economic development, such as the lack of social service consciousness of schoolrunning concept, the homogenization of school-running orientation and the lack of effective cooperation among the main elements. It focuses on the strategy of higher vocational education to serve regional economic development in the symbiotic development relationship from the aspects of updating the school-running concept, clarifying the school-running orientation and building the cooperation platform between government, industry, school and enterprise.