Abstract: Scientific research integrity is the difficulty of scientific research management in colleges and universities. The phenomenon of scientific research discredit is common in colleges and universities. There are two types of scientific research discredit colleges and universities: individual and collective, and the reasons and phenomena are different. Perfect scientific research integrity management system, improve scientific research ability and establish scientific research fault-tolerance mechanism, the whole flow of scientific research covered by integrity management, use classification evaluation ways and informatization technology to implement integrity monitoring, strengthen the discipline of scientific research discredit, purify the external scientific research environment, are the effective ways to construct the scientific research integrity in colleges and universities.