Abstract: Facing the current background of industry-education deep integration and the new requirements under the new normal of reform and development, higher vocational colleges must further deepen the innovation and reform of school-enterprise cooperation and talent cultivation mode, and explore the way of cultivating high-quality composite technical skilled talent to meet the needs of economic and social development. Based on the analysis of the problems existing in the process of school-enterprise cooperation in building industrial colleges, A school-enterprise deep cooperation education mode based on industry-education integration is explored, a new paradigm of school-enterprise cooperation in building co-construction of college campus, co-constitute of teachers, joint-progress of scientific research, joint-cultivation of talents and co-occurrence internationalization is proposed.