Abstract: The integration of science and education is an important path for the high-quality development of vocational education, and courses are the key carriers for its implementation. In view of the predicament faced during the implementation of the integration of science and education in vocational education, based on the theoretical logic of the integration of science and education, a talent cultivation model of "team as the foundation, production as the basis, scientific research as the engine, students as the core, reform as the driving force, multi-channel integration, and four-way connection " for the integration of science and education has been constructed. Taking the higher vocational water conservancy course " Hydraulic Analysis and Calculation" as an example, the organic connection paths of the education chain, talent chain, industrial chain, and innovation chain have been explored, forming a multi-dimensional linkage of production, scientific research, education, and innovation, with the aim of providing practical references for the implementation of the integration of science and education in higher vocational specialized courses and the cultivation of innovative skilled talents.