Abstract: In the context of the era of "Mass Entrepreneurship and Innovation", higher vocational colleges are actively engaged in the reform of innovation and entrepreneurship education and constructing an innovation and entrepreneurship ecosystem to enhance the quality of talent cultivation and social service capabilities. Regarding the problems existing in the construction of the innovation and entrepreneurship ecosystem in higher vocational colleges, such as the insufficient systematization of the "Innovation and Entrepreneurship" course system, the low correlation between scientific and technological innovation platforms and talent cultivation, and the incomplete construction of "Innovation and Entrepreneurship" practice platforms, it proposes multi-dimensional solutions, including constructing a course system that aligns with the cultivation of "Innovation and Entrepreneurship" capabilities, enhancing the collaborative educational capacity of "Innovation and Entrepreneurship" practice platforms, and optimizing the working mechanism for promoting "Innovation and Entrepreneurship" education. Taking the "Innovation and Entrepreneurship" work practice of Yellow River Conservancy Technical Institute as an example, the effectiveness of the solutions is verified, with the aim of providing a referential path for innovation and entrepreneurship education in higher vocational colleges and contributing vocational education strength to promoting high-quality economic and social development.