Abstract: In order to evaluate the disaster consequence of benzene leakage during transportation, the accident consequence simulation software ALOHA is used to analyze the diffusion range and toxic area of benzene tank truck leakage. The influence range of fire thermal radiation and shock wave overpressure is analyzed after the benzene ignition. The human vulnerability model is used to calculate the lethal probability and personal risk value in the disaster area. With Google Earth and Surfer software, the map of accident affected area is drawn.